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研究论文

非传染慢性病免疫治疗与治疗性疫苗

  1. A Rationally Designed TNF-alpha Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice ?Zhang L, Wang J, Xu AZ, Zhong CH, Lu WG, Deng L, Li RXPlos One 2016, 11(9):e0163080. ?类风湿性关节炎治疗性疫苗。 《自然》系列风湿病杂志在创新亮点(Innovation) 版报道,标题称我们的工作为肿瘤坏死因子疫苗走向成功铺路。Collison J. Rheumatoid arthritis: Paving the way for TNF vaccines.Nat Rev Rheumatol. 2016 Dec;12(12):692.
  2. Immunogenicity and efficacy of a rationally designed vaccine against vascular endothelial growth factor in mouse solid tumor models, Xu AZ ,Zhang L, Chen YY,Lin ZB, Li RX, Cancer Immunology, Immunotherapy, 2016,Onlined, DOI: 10.1007/s00262-016-1928-0. 癌症疫苗免疫治疗
  3. Coagulation Factor XI vaccination: an alternative strategy to prevent thrombosis, Zhong CH, Zhang L,? Chen L, Deng L and Li RX,J Thromb & Haemost Onlined, DOI: 10.1111/jth.13561 血管梗塞疾病治疗性疫苗
  4. Cytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit. Wuguang Lu,Lingchong Qiu,Zhanpeng Yan,Zhibing Lin,Meng Cao,Chunping Hu,Zhigang Wang,Jin Wang,Ye Yu,Xiaoyang Cheng,Peng Cao,and Rongxiu Li. Oncotarget2015633):34537~34548. 癌症治疗性疫苗
  5. IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia ?Xu AZ, Bhanumathy KK, Wu J, Ye ZM, Freywald A, Leary SC, Li RX, Xiang J, Cell Biosci 2016, 6:30. 癌症免疫治疗

 

新候选生物靶标发现

  1. Improving basic and membrane protein MS detection of the culture filtrate proteins from Mycobacterium tuberculosis H37Rv by biomimetic affinity pre‐fractionation. Guorong Ma,Fuqiang Zhou,Lina Gao,Zhanqiang Sun,Li Deng,Shulin Zhang,Rongxiu Li. Proteomics · April 2017. DOI: 10.1002/pmic.201600177。
  2. Staged-probability strategy of processing shotgun proteomic data to discover more functionally important proteins? Hong Xu,Guijun Ma,Qingqiao Tan,Qiang Zhou,Wen Su,Rongxiu Li ?Protein & Cell 3(2):140-7 · January 2012. DOI: 10.1007/s13238-011-1129-8 · Source: PubMed
  3. A fluorescence-based method for the characterization of amino loading density on the flat surface of functionalized glass tubes. Long Ye, Guorong Ma, Conghao Zhong, Yuanwei Yan, Jinting Pan, Guijun Ma and Rongxiu Li. Anal. Methods, 2011, 3, 2524
  4. The Improvement of LC-MS/MS Proteomic Detection with Biomimetic Affinity Fractionation. Rongxiu Li,Qing-Qiao Tan,De-Xian Dong .Chapter · In book: Biomimetic Based Applications April 2011 DOI: 10.5772/13870 · Source: InTech
  5. Vitreous and serum levels of transthyretin (TTR) in high myopia patients are correlated with ocular pathologies. Jun Shao,Yu Xin,Rongxiu Li,Ying Fan. Clinical biochemistry 44(8-9):681-5 · March 2011 DOI: 10.1016/j.clinbiochem.2011.03.032
  6. Mutational Analysis of Highly Conserved Residues in the Phage PhiC31 Integrase Reveals Key Amino Acids Necessary for the DNA Recombination, Shaohui Liu,Jinfang Ma,Wei Wang,Maoxiang Zhang,Qingting Xin,Siman Peng,Rongxiu Li,Huanzhang Zhu. PLoS ONE 5(1):e8863 · January 2010 DOI: 10.1371/journal.pone.0008863
  7. Pre-fractionation of rat liver cytosol proteins prior to mass spectrometry-based proteomic analysis using tandem biomimetic affinity chromatography, Qingqiao Tan, Dexian Dong, Long Ye, Chenxi Huo, Feiyun Huang and Rongxiu Li, Journal of Molecular recognition, 23(2010):93 - 100 .
  8. Rapid monitoring of mRNA levels using a molecular beacon during fermentation production of phenazine-1-carboxylic acid, Dexian Dong, Yanping Pang, Qian Gao, Xianqing Huang, Yuquan Xu, Rongxiu Li,Journal of Biotechnology. 145(3)(2010):310-6.
  9. Combined usage of cascade affinity fractionation and LC-MS/MS for the proteomics of adult mouse testis , Qingqiao Tan, Dexian Dong, Long Ye, Rongxiu Li, Journal of Separation Science Volume 32, Issue 22, pages 3871–3879, November 2009.
  10. Measurement of the onset temperature of irreversible inactivation of proteins using FITC as a fluorescent reporter. Zhong CH, Wang Y, Ma GJ, Li RX,Anal Methods 2016, 8(18):3809-15.
  11. Phenazine-1- carboxylic acid derivatives: Long Ye, Hongyan Zhang, Hong Xu, Qi Zou, Chao Cheng, Dexian Dong, Yuquan Xu, Rongxiu Li, Design, synthesis and biological evaluation against Rhizoctonia solani Kuhn, Bioorganic& Medicinal Chemistry Letters, 20 (2010) :7369–7371.
  12. Comparative Analysis of Depurination Catalyzed by Ricin A-chain on Synthetic 32mer and 25mer Oligoribonucleotides Mimicking the Sarcin/Ricin Domain of the Rat 28S rRNA and E.coli 23S rRNA. Qingqiao Tan, Dexian Dong,Rongxiu Li, Wangyi Liu, Journal of Biotechnology. 2009, 139, 156-162.
  13. An easily-automated assay for the physiological state quantification of Pseudomonas sp. M18, Dexian Dong , Kejun Zhou, Quan Zhou, Xianqing Huang, Yuquan Xu, Rongxiu Li, Analytica Chimica Acta 2008, 630, 40-46.
  14. Development and application of molecularly imprinted polymers as solid-phase sorbents for erythromycin extraction. Song S, Wu A, Shi X, Li R, Lin Z, Zhang D, Anal Bioanal Chem. 2008 390(8):2141-50.
  15. Molecularly imprinted polymer microspheres for solid-phase extraction of chloramphenicol residues in foods. Shi X, Wu A, Zheng S, Li R, Zhang D, Journal of Chromatography B 2007, 850(1-2):24-30.
  16. Identification and Characterization of Bioactive Compounds Targeting Uropathogenic Escherichia coli from Sanjin Tablets,Jie Meng,Zhun Zou,Chen Lu,Tingting Li,Cui Wang,Zheng Wang,Donggai Zhai,Wei Liu,Jieming Zou,Rongxiu Li.  Journal of Chemistry? August 2015 DOI: 10.1155/2015/789809

生物药新型仿生亲和纯化技术

  1. Biomimetic affinity purification of Candida antarctica lipase B. Hongyan Yao,Tian Zhang,Hongwei Xue,Kexuan Tang,Rongxiu Li. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · November 2011. 879(32):3896-900
  2. Design and synthesis of affinity ligands and relation of their structure with adsorption of proteins. Long Ye,Aizhang Xu,Chao Cheng,Li Zhang,Chenxi Huo,Feiyun Huang,Hong Xu,Rongxiu LiJournal of Separation Science. 2011, 34, 3145–3150
  3. Structural and biological characterizations of a novel acutobin-like enzyme isolated from the snake venom of Deinagkistrodon acutus, Yu Xin, Dexian Dong, Dezhao Chen,Rongxiu Li, Biotechnology and Applied Biochemistry Biotechnol Appl Biochem. 2009 Jun;53(Pt 2):123-31. doi: 10.1042/BA20080073.
  4. Affinity purification of egg yolk immunoglobulins (IgY)with a stable synthetic ligand, Dexian Dong, Haoran Liu, Qishi Xiao, Rongxiu Li, Journal of Chromatography B, 2008, 870, 51-54
  5. Biomimetic affinity purification of cardiotoxin and its pharmacological effects on the nervous system, Dexian Dong, HR Liu, QS Xiao, T Wang, HQ Liu, RX Li, Journal of Molecular Recognition 2008, 21, 148-153.
  6. Utilizing a library of synthetic affinity ligand for the enrichment, depletion and one-step purification of leech proteins, Dexian Dong, YL Gui, DZ Chen, RX Li, Journal of Molecular recognition 2008, 21, 163-168
  7. Affinity purification of serine proteinase from Deinagkistrodon acutus venom, Yu Xin, DX Dong, T Wang, RX Li, Journal of Chromatography B, 859 (2007) 111–118
  8. Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs. Shi X, Wu A, Qu G, Li R, Zhang D. Biomaterials. 2007,28(25):3741-9.
  9. Novel biomimetic affinity ligands for human tissue plasminogen activator. Wu F, Yu J, Li R, Biochem Biophys Res Commun. 2007,355(3):673-8; 363(4):1057.
  10. Design, Synthesis and Application of an Artificial Protein A,Rongxiu Li, Dowd V, Stewart DJ, Burton SJ, Lowe CR. Nature Biotechnology.1998 Feb. 16(2): 190-195 李荣秀剑桥大学博士研究课题

 

生物质与生物能源

  1. In Situ Biodiesel Production from Fast-Growing and High Oil Content Chlorella pyrenoidosa in Rice Straw Hydrolysate. Penglin Li,Xiaoling Miao,Rongxiu Li,Jian-Jiang Zhong, Journal of Biomedicine and Biotechnology. 2011(7):141207 · January 2011 DOI: 10.1155/2011/141207
  2. Detection and quantification assay of Prorocentrum sp. with Sandwich Hybridization and S1 Nuclease Protection,Qingsong Cai,RongXiu Li , ZhiGang Yu, Harmful Algae ,2006, 5, 300–309
  3. Identification and quantification of the toxic dinoflagellate Gymnodinium sp. with competitive enzyme-linked immunosorbent assay (cELISA),ZeYu Xin,ZhiGang Yu, TanChun Wang, Xin Hui, WanLi Gou, Jun Sun, Haigang Qi and RongXiu Li, Harmful Algae ,2005, 4(2), 297-307
  4. Phylogenetic analysis of a free-living strain of Symbiodinium isolated from Jiaozhou Bay, PR China. Wanli Gou, Jun Sun, XiuQin Li, Yu Zhen, Zeyu Xin, ZhiGang Yu, RongXiu Li, Journal of Experimental Marine Biology & Ecology, 2003, 296(2):135-144

 

专 著

  1. 《蛋白质结构模拟与设计》,李荣秀、魏冬青、冯雁 等编著, 化学工业出版社, 2011年5月, 北京. ISBN: 9787122101839
  2. 《生物高分子(第7卷 聚酰胺和蛋白质材料Ⅰ)》,(美)S.R.法内斯托克(S.R.Fahnestock),(德)A.斯泰因比歇尔(A.Steinbuchel)主编;李荣秀主译. 化学工业出版社, 2005-01-01, 北京. ISBN:9787502562106
  3. 《酶工程制药》,李平作,李荣秀编著,化学工业出版社, 2004年3月, 北京.
  4. 《分子仿生学及其应用》,李荣秀,杨金菊编著,化学工业出版社, 2003年1月, 北京. ISBN:7502542272, 9787502542276
 

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